SimpleDesign: A Joint Model for Protein Sequence and Structure Codesign
Updated 7 h ago · first seen 11 Sept 2026
paper_01M294AHKNZTFCVADHATRHY41E
- Published
- 11 Sept 2026
- T1 · 7 h ago
- arXiv
- 2609.03377
- T1 · 7 h ago
Abstract
Proteins are fundamental to biological processes, with their function determined by the complex interplay between the amino acid sequence and the three-dimensional structure. Developing generative models capable of understanding this intrinsically multi-modal relationship is crucial for fields like drug discovery and protein engineering. Existing models often rely on a multi-stage training process where autoencoders that tokenize data into latent representations are trained in a first stage. Secondly, a generative model is trained on the latent representation of the autoencoder(s), i.e…
Authors 7
Jiarui Lu, Yuyang Wang, Yizhe Zhang, Jiatao Gu, Navdeep Jaitly, Joshua M. Susskind, Miguel Ángel Bautista
Specification
- Paper
Source:Apple Machine Learning ResearchT1observed 7 h agohigh
- arXiv id
- 2609.03377
Source:Apple Machine Learning ResearchT1observed 7 h agohigh
Source:Apple Machine Learning ResearchT1observed 7 h agohigh
- Published
- 11 Sept 2026
Source:Apple Machine Learning ResearchT1observed 7 h agohigh
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Provenance
Attributed facts
6
Source tiers
T16
Freshest observation
7 h ago
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None
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- Published by
- Apple
As of
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Claim history · Abstract
Abstractabstract1
| Value | Valid from → to | Status | Source | Confidence | Extractor |
|---|---|---|---|---|---|
| Proteins are fundamental to biological processes, with their function determined by the complex interplay between the amino acid sequence and the three-dimensional structure. Developing generative models capable of understanding this intrinsically multi-modal relationship is crucial for fields like drug discovery and protein engineering. Existing models often rely on a multi-stage training process where autoencoders that tokenize data into latent representations are trained in a first stage. Secondly, a generative model is trained on the latent representation of the autoencoder(s), i.e… | → current | current | Apple Machine Learning ResearchT1 | high | deterministic |
Claims are temporal and append-only: a new observation closes the previous claim (valid_to) instead of overwriting it. Conflicting claims from different sources are kept side by side and flagged — never averaged. Methodology →
New paper: SimpleDesign: A Joint Model for Protein Sequence and Structure Codesign (Apple)
apple_ml
| Source | Document | Type | Tier | Last observed | Snapshots |
|---|---|---|---|---|---|
| Apple Machine Learning Research | machinelearning.apple.com/rss.xml | feed | T1· Official | 5 h ago | 1 |
| Apple Machine Learning Research | machinelearning.apple.com/research/simpledesign-protein-codesign | paper_page | T1· Official | 7 h ago | 1 |
Tier 1 = official/primary, 2 = quality secondary, 3 = community, 4 = unverified. Every snapshot is archived; see all sources and the methodology.