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Sequence-Informed Geometric Evaluation of RNA 3D Structures

arxiv.org/abs/2609.10644

quality89

Updated 3 h ago · first seen 11 Sept 2026

paper_01M294FPV62GCH1MA386GHAECF

Published
11 Sept 2026
T1 · 3 h ago
arXiv
2609.10644
T1 · 3 h ago
Category
q-bio.BM
T1 · 3 h ago

Abstract

Computational RNA structure pipelines generate many candidate conformations for the same sequence. Reliable evaluation therefore requires more than recognising plausible geometry, it requires determining whether that geometry is compatible with the sequence. We introduce SIRGE, a sequence-informed geometric evaluator that conditions structural representations on nucleotide embeddings from a pretrained RNA language model. Early results show that SIRGE outperforms established evaluators in Kendall--$\tau$ alignment, Top-1 selection, and Top-3 ranking. Controlled comparisons further show that sequence conditioning corrects errors made by an otherwise matched geometric model and improves target-level rank structure. These findings provide initial evidence that pretrained sequence representations supply ranking information that complements geometric reasoning.

Authors 8

Andrea Zerio, Yighua Yao, Alessandro Micheli, Roland G. Huber, Mile Sikic, Samir Bhatt, Andres R. Masegosa, Yuangang Pan

Specification

Official page

Source:arXiv (Atom API + RSS)T1observed 3 h agohigh

Arxiv announce type
cross

Source:arXiv (Atom API + RSS)T1observed 3 h agohigh

arXiv id
2609.10644

Source:arXiv (Atom API + RSS)T1observed 3 h agohigh

Categories
q-bio.BM, cs.LG

Source:arXiv (Atom API + RSS)T1observed 3 h agohigh

PDF

Source:arXiv (Atom API + RSS)T1observed 3 h agohigh

Primary category
q-bio.BM

Source:arXiv (Atom API + RSS)T1observed 3 h agohigh

Published
11 Sept 2026

Source:arXiv (Atom API + RSS)T1observed 3 h agohigh

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Provenance

Attributed facts

9

Source tiers

T19

Freshest observation

3 h ago

Conflicts

None