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Seamless Whole Slide Label-Free Virtual Staining

arxiv.org/abs/2609.10914

Updated 51 min ago · first seen 11 Sept 2026

paper_01M294H2Q95PCXCMW7TJ4JVCGN

Published
11 Sept 2026
T1 · 51 min ago
arXiv
2609.10914
T1 · 51 min ago
Category
eess.IV
T1 · 51 min ago

Abstract

Label-free virtual staining offers a compelling, non-destructive alternative to standard histopathology; however, its clinical adoption is hindered by the computational bottlenecks inherent to processing gigapixel Whole Slide Images (WSIs). Current deep learning approaches require patch-based inference to avoid memory constraints, which disrupts global tissue continuity and introduces tiling artifacts--displaying visible seams and color shifts. To address this, we introduce the Consistency Memory Bank (COMB), a novel label-free virtual staining framework that enforces spatial and channel consistency across tiles without memory bottlenecks. COMB decouples context storage from computation, utilizing a dynamic retrieval mechanism to fetch feature representations from adjacent tiles. This enables a retrieval-based context integration strategy that adopts local padding to resolve spatial discontinuities and neighbor-aware channel attention to stabilize statistical drift. Further optimized with a sliding window schedule to ensure minimal memory overhead, our method demonstrates superior performance over state-of-the-art baselines, achieving significant improvements in both perceptual fidelity and tiling consistency, while suggesting its downstream utility in tumor segmentation. Code is available at https://github.com/dou0000/COMB.

Authors 6

Dou Hoon Kwark, Kianoush Falahkheirkhah, Ji-hun Oh, Shirui Luo, Volodymyr Kindratenko, Rohit Bhargava

Specification

Official page

Source:arXiv (Atom API + RSS)T1observed 51 min agohigh

Arxiv announce type
cross

Source:arXiv (Atom API + RSS)T1observed 51 min agohigh

arXiv id
2609.10914

Source:arXiv (Atom API + RSS)T1observed 51 min agohigh

Categories
eess.IV, cs.CV, q-bio.QM

Source:arXiv (Atom API + RSS)T1observed 51 min agohigh

PDF

Source:arXiv (Atom API + RSS)T1observed 51 min agohigh

Primary category
eess.IV

Source:arXiv (Atom API + RSS)T1observed 51 min agohigh

Published
11 Sept 2026

Source:arXiv (Atom API + RSS)T1observed 51 min agohigh

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Provenance

Attributed facts

9

Source tiers

T19

Freshest observation

51 min ago

Conflicts

None