Representation learning of human cortical folding to reveal long lasting neurodevelopmental signatures
Updated 2 h ago · first seen 11 Sept 2026
paper_01M294FTKDWYM2GBT9S5BGSMGD
- Published
- 11 Sept 2026
- T1 · 2 h ago
- arXiv
- 2609.05438
- T1 · 2 h ago
- Category
- q-bio.QM
- T1 · 2 h ago
Abstract
-cross Abstract: The human brain folds in utero, primarily during late gestation. Shortly after birth, cortical folding patterns are established and remain stable thereafter, making them promising early neurodevelopmental markers. Yet it is unclear whether the representations given by current neuroimaging foundation models capture cortical folding variability. Here, we introduce Champollion, a self-supervised learning framework that learns interpretable local representations of cortical folding from structural MRI. Optimized on representative folding-related tasks, Champollion accurately captures known folding patterns across cortical regions and external datasets. In a comprehensive benchmark, it consistently outperforms neuroimaging and general-purpose foundation models. Furthermore, Champollion reveals richer genetic associations than conventional morphometric descriptors and identifies localized folding signatures associated with incomplete hippocampal inversion, prematurity, and maternal smoking. These results establish cortical folding as a rich and largely untapped source of neurodevelopmental information, and Champollion provides a unified framework for discovering, localizing and interpreting long lasting cortical folding signatures.
Authors 27
Julien Laval, Robin Guiavarch, Antoine Dufournet, Racim Menasria, Barth\'el\'emy Drabczuk, Cristobal Mendoza, Saeb Tounsi, Chikh Abdelghani Baroud, Merieme Bourenane, Vanessa Troiani, William Snyder, Marisa A Patti, Myl\`ene Moyal, Marion Plaze, Arnaud Cachia, Federica Santacroce, Giorgia Committeri, Claire Cury, Kevin De Matos, Olivier Colliot, Zhong Yi Sun, Clara Fischer, Vincent Frouin, Pietro Gori, Denis Rivi\`ere, Jo\"el Chavas, Jean-Fran\c{c}ois Mangin
Specification
- Official page
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- Arxiv announce type
- replace
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- arXiv id
- 2609.05438
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- Categories
- q-bio.QM, cs.CV, cs.LG
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- Primary category
- q-bio.QM
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- Published
- 11 Sept 2026
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
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Provenance
Attributed facts
9
Source tiers
T19
Freshest observation
2 h ago
Conflicts
None
No models linked to this paper yet.
- Authors
- Julien Laval, Robin Guiavarch, Antoine Dufournet
As of
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Claim history · Abstract
Abstractabstract1
| Value | Valid from → to | Status | Source | Confidence | Extractor |
|---|---|---|---|---|---|
| -cross Abstract: The human brain folds in utero, primarily during late gestation. Shortly after birth, cortical folding patterns are established and remain stable thereafter, making them promising early neurodevelopmental markers. Yet it is unclear whether the representations given by current neuroimaging foundation models capture cortical folding variability. Here, we introduce Champollion, a self-supervised learning framework that learns interpretable local representations of cortical folding from structural MRI. Optimized on representative folding-related tasks, Champollion accurately captures known folding patterns across cortical regions and external datasets. In a comprehensive benchmark, it consistently outperforms neuroimaging and general-purpose foundation models. Furthermore, Champollion reveals richer genetic associations than conventional morphometric descriptors and identifies localized folding signatures associated with incomplete hippocampal inversion, prematurity, and maternal smoking. These results establish cortical folding as a rich and largely untapped source of neurodevelopmental information, and Champollion provides a unified framework for discovering, localizing and interpreting long lasting cortical folding signatures. | → current | current | arXiv (Atom API + RSS)T1 | high | deterministic |
Claims are temporal and append-only: a new observation closes the previous claim (valid_to) instead of overwriting it. Conflicting claims from different sources are kept side by side and flagged — never averaged. Methodology →
- New paperPaperRepresentation learning of human cortical folding to reveal long lasting neurodevelopmental signatures
New paper: Representation learning of human cortical folding to reveal long lasting neurodevelopmental signatures
arxiv
| Source | Document | Type | Tier | Last observed | Snapshots |
|---|---|---|---|---|---|
| arXiv (Atom API + RSS) | rss.arxiv.org/rss/cs.LG | feed | T1· Official | 48 min ago | 1 |
Tier 1 = official/primary, 2 = quality secondary, 3 = community, 4 = unverified. Every snapshot is archived; see all sources and the methodology.