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ProsMAE: Multi-Source MAE Pretraining for ISUP Grade Classification

arxiv.org/abs/2607.08162

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Updated 6 h ago · first seen 11 Sept 2026

paper_01M294FTAZRE3R5RXNGJ67EBPQ

Published
11 Sept 2026
T1 · 6 h ago
arXiv
2607.08162
T1 · 6 h ago
Category
cs.CV
T1 · 6 h ago

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-cross Abstract: Whole slide images (WSIs) provide rich diagnostic information for computational pathology, but their gigapixel scale, stain variation, scanner differences, tissue artifacts, and limited expert annotation make robust model training challenging. This paper presents a multi-source Masked Autoencoder (MAE) framework, named ProsMAE, for histopathology representation learning. Tiles from Prostate cANcer graDe Assessment (PANDA), CAncer MEtastases in LYmph nOdes challeNge 2017 (CAMELYON17), and BReAst Carcinoma Subtyping (BRACS) are used for ProsMAE pretraining to expose the encoder to diverse tissue morphology and acquisition conditions. The learned encoder is transferred for International Society of Urological Pathology (ISUP) grade classification through ProsCLS, using a frozen encoder and a linear classification head. ProsMAE achieved a higher mean validation quadratic weighted kappa (QWK) than the vanilla MAE frozen linear-probe baseline under the evaluated disjoint PANDA split. Repeated-split evaluation remains necessary to further establish robustness across split compositions.currentcurrentarXiv (Atom API + RSS)T1highdeterministic

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