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Scale-Aware 3D Deep Learning for Robust Brain Metastasis Detection in Multimodal MRI

arxiv.org/abs/2609.10825

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Updated 8 h ago · first seen 11 Sept 2026

paper_01M294FQ61N66V38TZRWP4TWQ0

Published
11 Sept 2026
T1 · 8 h ago
arXiv
2609.10825
T1 · 8 h ago
Category
eess.IV
T1 · 8 h ago

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9 claims · 9 properties

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https://arxiv.org/abs/2609.10825currentcurrentarXiv (Atom API + RSS)T1highdeterministic

Abstractabstract1

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Detecting brain metastases in magnetic resonance imaging (MRI) remains challenging because lesions vary widely in size and appearance, with very small metastases occupying only a minute fraction of a three-dimensional input. We investigate whether combining different spatial fields of view (FOVs) improves lesion detection in multimodal MRI and present a scale-aware 3D deep-learning framework. The method uses independently trained $96^3$ and $64^3$ 3D U-Nets whose whole-volume probability maps are combined by weighted late fusion. This design allows us to study the effect of spatial context separately from image resolution and modality choice. On a 97-patient development cohort, cross-FOV fusion improved lesion-level precision and F1 while substantially reducing false positives relative to the individual models. A same-FOV ensemble control showed that these gains were not explained solely by averaging independently trained networks, supporting a contribution from complementary spatial context. An exploratory cross-FOV agreement filter reduced false positives but did not improve overall F1. These results support cross-FOV probability fusion as a simple and computationally practical strategy for improving the precision-false-positive trade-off in 3D brain-metastasis detection.currentcurrentarXiv (Atom API + RSS)T1highdeterministic

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crosscurrentcurrentarXiv (Atom API + RSS)T1highdeterministic

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2609.10825currentcurrentarXiv (Atom API + RSS)T1highdeterministic

Authorsauthors1

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Sylvain Jaume, Hongming Wang, Simon K. WarfieldcurrentcurrentarXiv (Atom API + RSS)T1highdeterministic

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eess.IV, cs.CV, cs.LGcurrentcurrentarXiv (Atom API + RSS)T1highdeterministic

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https://arxiv.org/pdf/2609.10825currentcurrentarXiv (Atom API + RSS)T1highdeterministic

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eess.IVcurrentcurrentarXiv (Atom API + RSS)T1highdeterministic

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11 Sept 2026currentcurrentarXiv (Atom API + RSS)T1highdeterministic

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