SafeImpute: Reliable Clinical Data Imputation via Conformal Selection
Updated 7 h ago · first seen 11 Sept 2026
paper_01M294FSA8WH7DEWYQ1BEQH1ZC
- Published
- 11 Sept 2026
- T1 · 7 h ago
- arXiv
- 2607.05613
- T1 · 7 h ago
- Category
- cs.LG
- T1 · 7 h ago
Abstract
Clinical care often relies on key laboratory indicators, yet real-world patient visits are sparse and tests are ordered irregularly, leading to pervasive missingness. While many imputation methods improve average accuracy, they provide limited guidance on which imputed values are reliable enough for high-stakes downstream use. In this work, we study reliable clinical imputation, aiming to produce accurate imputations while selectively releasing the reliable results, with statistical control over clinically unacceptable errors. To achieve this goal, we propose SafeImpute, a reliable imputation framework for irregular and sparse clinical longitudinal records. SafeImpute constructs an event graph that captures both intra-patient temporal trajectories and inter-patient clinical similarity, and learns imputations with a two-relation GNN and adaptive fusion, regularized by an auxiliary masked reconstruction objective. For reliability guarantees, SafeImpute converts a proxy risk score into conformal p-values and applies the Benjamini--Hochberg procedure to control the false discovery rate (FDR) of unacceptable errors among released imputations at a user-specified tolerance. Experiments on our Mayo Clinic data, the public MIMIC-III and MIMIC-IV datasets show that SafeImpute achieves strong imputation accuracy while providing reliable error control, outperforming diverse baselines in both standard imputation evaluation and FDR-controlled selective-release evaluation.
Authors 5
Xinrui He, Mengting Ai, Junting Wang, Curtiss B. Cook, Jingrui He
Specification
- Official page
Source:arXiv (Atom API + RSS)T1observed 7 h agohigh
- Arxiv announce type
- replace
Source:arXiv (Atom API + RSS)T1observed 7 h agohigh
- arXiv id
- 2607.05613
Source:arXiv (Atom API + RSS)T1observed 7 h agohigh
- Categories
- cs.LG
Source:arXiv (Atom API + RSS)T1observed 7 h agohigh
- DOI
- 10.1145/3770855.3817967
Source:arXiv (Atom API + RSS)T1observed 7 h agohigh
Source:arXiv (Atom API + RSS)T1observed 7 h agohigh
- Primary category
- cs.LG
Source:arXiv (Atom API + RSS)T1observed 7 h agohigh
- Published
- 11 Sept 2026
Source:arXiv (Atom API + RSS)T1observed 7 h agohigh
Each value shows its source, tier and observation time. Conflicting claims are kept side by side and flagged — never averaged. How AI Atlas records facts →
Provenance
Attributed facts
10
Source tiers
T110
Freshest observation
7 h ago
Conflicts
None
No models linked to this paper yet.
- Authors
- Xinrui He, Mengting Ai, Junting Wang
As of
Rewind the record: see this entity's attributes exactly as AI Atlas knew them on a given day.
Claim history · Abstract
Abstractabstract1
| Value | Valid from → to | Status | Source | Confidence | Extractor |
|---|---|---|---|---|---|
| Clinical care often relies on key laboratory indicators, yet real-world patient visits are sparse and tests are ordered irregularly, leading to pervasive missingness. While many imputation methods improve average accuracy, they provide limited guidance on which imputed values are reliable enough for high-stakes downstream use. In this work, we study reliable clinical imputation, aiming to produce accurate imputations while selectively releasing the reliable results, with statistical control over clinically unacceptable errors. To achieve this goal, we propose SafeImpute, a reliable imputation framework for irregular and sparse clinical longitudinal records. SafeImpute constructs an event graph that captures both intra-patient temporal trajectories and inter-patient clinical similarity, and learns imputations with a two-relation GNN and adaptive fusion, regularized by an auxiliary masked reconstruction objective. For reliability guarantees, SafeImpute converts a proxy risk score into conformal p-values and applies the Benjamini--Hochberg procedure to control the false discovery rate (FDR) of unacceptable errors among released imputations at a user-specified tolerance. Experiments on our Mayo Clinic data, the public MIMIC-III and MIMIC-IV datasets show that SafeImpute achieves strong imputation accuracy while providing reliable error control, outperforming diverse baselines in both standard imputation evaluation and FDR-controlled selective-release evaluation. | → current | current | arXiv (Atom API + RSS)T1 | high | deterministic |
Claims are temporal and append-only: a new observation closes the previous claim (valid_to) instead of overwriting it. Conflicting claims from different sources are kept side by side and flagged — never averaged. Methodology →
New paper: SafeImpute: Reliable Clinical Data Imputation via Conformal Selection
arxiv
| Source | Document | Type | Tier | Last observed | Snapshots |
|---|---|---|---|---|---|
| arXiv (Atom API + RSS) | rss.arxiv.org/rss/cs.LG | feed | T1· Official | 10 min ago | 1 |
Tier 1 = official/primary, 2 = quality secondary, 3 = community, 4 = unverified. Every snapshot is archived; see all sources and the methodology.