Domain Elastic Transform: Bayesian Function Registration for High-Dimensional Scientific Data
Updated 2 h ago · first seen 11 Sept 2026
paper_01M294H448QCT63MEP6EGPDFJC
- Published
- 11 Sept 2026
- T1 · 2 h ago
- arXiv
- 2603.21235
- T1 · 2 h ago
- Category
- stat.ML
- T1 · 2 h ago
Abstract
-cross Abstract: Nonrigid registration is conventionally divided into point set registration, which aligns sparse geometries, and image registration, which aligns continuous intensity fields on regular grids. This dichotomy is limiting for emerging scientific data such as spatial transcriptomics, where high-dimensional vector-valued functions, e.g., gene expression, are defined on irregular sparse manifolds. Researchers must therefore either sacrifice single-cell resolution through voxelization or ignore functional signals in favor of geometric alignment. We propose Domain Elastic Transform (DET), a grid-free probabilistic framework that jointly aligns geometry and function. By treating data as functions on irregular domains, DET registers high-dimensional signals directly without binning. Within a generalized Bayesian formulation, domain deformation is modeled as elastic motion guided by a joint spatial-functional likelihood. DET is fully unsupervised and scalable through registration on sampled points followed by displacement interpolation. We evaluate DET on MERFISH mouse-brain slices and Stereo-seq mouse-embryo atlases. On a 90-case MERFISH benchmark with severe perturbations and no prior initialization, DET achieved the strongest spatial overlap and topology among the evaluated pipelines, while an accelerated PASTE2 variant achieved the highest label-transfer ARI. In an atlas-scale MOSTA feasibility study without cross-stage ground truth, nonrigid refinement improved several within-pipeline anatomical-domain and boundary-consistency measures. These results suggest that grid-free function registration complements point-set, image-based, and optimal-transport approaches for high-dimensional scientific data. The DET implementation is available at https://github.com/ohirose/bcpd (since Mar, 2025).
Authors 2
Osamu Hirose, Emanuele Rodola
Specification
- Official page
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- Arxiv announce type
- replace
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- arXiv id
- 2603.21235
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- Categories
- stat.ML, cs.AI, cs.CV
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- Primary category
- stat.ML
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- Published
- 11 Sept 2026
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
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2 h ago
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- Authors
- Osamu Hirose, Emanuele Rodola
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Claim history · Abstract
Abstractabstract1
| Value | Valid from → to | Status | Source | Confidence | Extractor |
|---|---|---|---|---|---|
| -cross Abstract: Nonrigid registration is conventionally divided into point set registration, which aligns sparse geometries, and image registration, which aligns continuous intensity fields on regular grids. This dichotomy is limiting for emerging scientific data such as spatial transcriptomics, where high-dimensional vector-valued functions, e.g., gene expression, are defined on irregular sparse manifolds. Researchers must therefore either sacrifice single-cell resolution through voxelization or ignore functional signals in favor of geometric alignment. We propose Domain Elastic Transform (DET), a grid-free probabilistic framework that jointly aligns geometry and function. By treating data as functions on irregular domains, DET registers high-dimensional signals directly without binning. Within a generalized Bayesian formulation, domain deformation is modeled as elastic motion guided by a joint spatial-functional likelihood. DET is fully unsupervised and scalable through registration on sampled points followed by displacement interpolation. We evaluate DET on MERFISH mouse-brain slices and Stereo-seq mouse-embryo atlases. On a 90-case MERFISH benchmark with severe perturbations and no prior initialization, DET achieved the strongest spatial overlap and topology among the evaluated pipelines, while an accelerated PASTE2 variant achieved the highest label-transfer ARI. In an atlas-scale MOSTA feasibility study without cross-stage ground truth, nonrigid refinement improved several within-pipeline anatomical-domain and boundary-consistency measures. These results suggest that grid-free function registration complements point-set, image-based, and optimal-transport approaches for high-dimensional scientific data. The DET implementation is available at https://github.com/ohirose/bcpd (since Mar, 2025). | → current | current | arXiv (Atom API + RSS)T1 | high | deterministic |
Claims are temporal and append-only: a new observation closes the previous claim (valid_to) instead of overwriting it. Conflicting claims from different sources are kept side by side and flagged — never averaged. Methodology →
- New paperPaperDomain Elastic Transform: Bayesian Function Registration for High-Dimensional Scientific Data
New paper: Domain Elastic Transform: Bayesian Function Registration for High-Dimensional Scientific Data
arxiv
| Source | Document | Type | Tier | Last observed | Snapshots |
|---|---|---|---|---|---|
| arXiv (Atom API + RSS) | rss.arxiv.org/rss/cs.CV | feed | T1· Official | 2 h ago | 1 |
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