A Trust-Network-Based Federated Learning Framework for Multi-Center Aging Clock Prediction
Updated 2 h ago · first seen 11 Sept 2026
paper_01M294GN6V7Y5T59T3M61XWCW8
- Published
- 11 Sept 2026
- T1 · 2 h ago
- arXiv
- 2609.10108
- T1 · 2 h ago
- Category
- cs.LG
- T1 · 2 h ago
Abstract
Aging clocks quantify biological aging and help characterize individual health status. What protein interactions are important for accurate aging clocks, and are they zeroth-order or higher-order? Addressing these questions requires learning from large molecular datasets distributed across medical centers, where privacy constraints prevent centralized data sharing. Federated learning offers a natural solution but faces four challenges in this setting: limited local sample sizes, sparse and directional inter-center trust, the need to retain discriminative age prediction while supporting interpretation, and model drift and forgetting under heterogeneous cross-center data. We propose TNFL, a trust-network-based federated learning framework that progressively propagates models along directed pairwise trust relations without centralized aggregation. TNFL combines an age-aware mixture-of-experts model with generative replay to preserve previously learned information and reduce forgetting and drift. Experiments across multiple molecular datasets show that TNFL enables effective aging-clock prediction with limited local data, provides interpretable age-dependent prediction patterns, and maintains stable performance across interaction orders. To investigate the biological questions, we analyze TNFL-identified pairwise protein interactions and their higher-order organization through functional and network analyses. The identified interactions repeatedly form coordinated higher-order subnetworks spanning multiple aging-related biological systems, with several proteins recurring across subnetworks. These findings suggest that TNFL captures molecular relationships beyond isolated pairwise associations and reveals coherent higher-order biological organization associated with aging.
Authors 10
Chunxu Zhang, Bo Li, Wenliang Wang, Yang Liu, Di Jiang, Yuan Huang, Yo-ichi Nabeshima, Akinori Yamamura, Bo Yang, Qiang Yang
Specification
- Official page
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- Arxiv announce type
- cross
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- arXiv id
- 2609.10108
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- Categories
- cs.LG, cs.AI
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- Primary category
- cs.LG
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
- Published
- 11 Sept 2026
Source:arXiv (Atom API + RSS)T1observed 2 h agohigh
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Provenance
Attributed facts
9
Source tiers
T19
Freshest observation
2 h ago
Conflicts
None
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- Authors
- Chunxu Zhang, Bo Li, Wenliang Wang
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Claim history · Abstract
Abstractabstract1
| Value | Valid from → to | Status | Source | Confidence | Extractor |
|---|---|---|---|---|---|
| Aging clocks quantify biological aging and help characterize individual health status. What protein interactions are important for accurate aging clocks, and are they zeroth-order or higher-order? Addressing these questions requires learning from large molecular datasets distributed across medical centers, where privacy constraints prevent centralized data sharing. Federated learning offers a natural solution but faces four challenges in this setting: limited local sample sizes, sparse and directional inter-center trust, the need to retain discriminative age prediction while supporting interpretation, and model drift and forgetting under heterogeneous cross-center data. We propose TNFL, a trust-network-based federated learning framework that progressively propagates models along directed pairwise trust relations without centralized aggregation. TNFL combines an age-aware mixture-of-experts model with generative replay to preserve previously learned information and reduce forgetting and drift. Experiments across multiple molecular datasets show that TNFL enables effective aging-clock prediction with limited local data, provides interpretable age-dependent prediction patterns, and maintains stable performance across interaction orders. To investigate the biological questions, we analyze TNFL-identified pairwise protein interactions and their higher-order organization through functional and network analyses. The identified interactions repeatedly form coordinated higher-order subnetworks spanning multiple aging-related biological systems, with several proteins recurring across subnetworks. These findings suggest that TNFL captures molecular relationships beyond isolated pairwise associations and reveals coherent higher-order biological organization associated with aging. | → current | current | arXiv (Atom API + RSS)T1 | high | deterministic |
Claims are temporal and append-only: a new observation closes the previous claim (valid_to) instead of overwriting it. Conflicting claims from different sources are kept side by side and flagged — never averaged. Methodology →
- New paperPaperA Trust-Network-Based Federated Learning Framework for Multi-Center Aging Clock Prediction
New paper: A Trust-Network-Based Federated Learning Framework for Multi-Center Aging Clock Prediction
arxiv
| Source | Document | Type | Tier | Last observed | Snapshots |
|---|---|---|---|---|---|
| arXiv (Atom API + RSS) | rss.arxiv.org/rss/cs.AI | feed | T1· Official | 2 h ago | 1 |
Tier 1 = official/primary, 2 = quality secondary, 3 = community, 4 = unverified. Every snapshot is archived; see all sources and the methodology.